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Previous controlled trials with oral administration of allergen have not demonstrated any treatment effect in patients with allergic rhinoconjunctivitis or asthma. In the present double-blind, placebo-controlled trial, we have tested the effect of oral immunotherapy in adult patients with birch pollinosis. Thirty-nine patients completed this 18-month study comprising two birch pollen seasons. The patients received enterosoluble capsules daily, and the actively treated patients reached a cumulated dose of 280 times 10(6) biologic units of birch pollen extract, which is about 200 times higher than the dose used in conventional subcutaneous immunotherapy. We found a significant decrease in eye symptom scores and conjunctival sensitivity to birch pollen, as determined by conjunctival provocation test, as well as a numerical but nonsignificant decrease in nasal symptom scores, nasal sensitivity as determined by nasal provocation test, and antiallergic medication. The treatment was safe, and only a few slight side effects were observed. We thus conclude that our study demonstrates a clinical effect of oral immunotherapy in birch pollinosis.
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B Björksten, and
S Dreborg, and
M Søborg, and
B Weeke
February 1938,
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B Weeke
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B Weeke
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Science (New York, N.Y.),
E Taudorf, and
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A Lanner, and
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B Weeke
January 2011,
International archives of allergy and immunology,
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M Søborg, and
B Weeke
December 1985,
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M Søborg, and
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E Taudorf, and
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March 1960,
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E Taudorf, and
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July 1951,
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E Taudorf, and
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December 1925,
Science (New York, N.Y.),
