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AQP4 autoantibodies in patients with idiopathic normal pressure hydrocephalus. 2020
Matteo Gastaldi, and
Massimiliano Todisco, and
Giorgia Carlin, and
Silvia Scaranzin, and
Elisabetta Zardini, and
Brigida Minafra, and
Roberta Zangaglia, and
Anna Pichiecchio, and
Markus Reindl, and
Sven Jarius, and
Claudio Pacchetti, and
Diego Franciotta
Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy; Neuro-oncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy. Electronic address: matteo.gastaldi@mondino.it.
Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients. We collected serum and cerebrospinal fluid (CSF) from 43 iNPH patients and 35 with other neurodegenerative conditions, and serum from 43 healthy subjects. All samples were tested for AQP4-IgG/IgA/IgM antibodies using a live cell-based assay. No patients or controls had serum/CSF AQP4-IgG/IgA. One/43 iNPH patient and 0/43 controls tested positive for serum AQP4-IgM. The AQP4-IgM-positive iNPH patient had no clinico-radiological distinctive features. AQP4 antibodies are unlikely to play a role in iNPH pathogenesis.
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