Risk factors for carcinoma ex pleomorphic adenoma in patients presenting with recurrence after resection of pleomorphic adenoma. 2021

Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.

In patients presenting with recurrent pleomorphic adenoma (rPA), clinical evaluation can fail to recognize carcinoma ex PA (cxPA). We aim to identify the risk factors for cxPA. This is a single institution retrospective case-control study from 2000 to 2015. CxPA was diagnosed based on surgical pathology. Demographics, clinical, and social histories were collected. A number of 13/106 (12.3%) patients were diagnosed with cxPA, of which only 4/13 (31%) had clinical features suspicious for malignancy. Compared to benign rPA, factors associated with cxPA included age >50 (odds ratio [OR] 6.67, 95% confidence interval [CI]: 1.71-25.98, P < .01), >10 pack-years of smoking history (OR 3.36, 95% CI: 1.01-11.14, P = .04), and the largest tumor being >2 cm on pathology (OR 4.42, 95% CI: 1.14-17.10, P = .03). In patients presenting with rPA, risk factors for malignant transformation include age >50, significant smoking history, and tumors larger than 2 cm. Clinical signs of malignancy such as rapid growth or pain are not always present.

UI MeSH Term Description Entries
D008949 Adenoma, Pleomorphic A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed) Mixed Salivary Gland Tumor,Salivary Gland Tumor, Mixed,Syringoma, Chondroid,Adenomas, Pleomorphic,Chondroid Syringoma,Chondroid Syringomas,Pleomorphic Adenoma,Pleomorphic Adenomas,Syringomas, Chondroid
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D012468 Salivary Gland Neoplasms Tumors or cancer of the SALIVARY GLANDS. Cancer of Salivary Gland,Non-Sebaceous Lymphadenomas,Salivary Gland Cancer,Salivary Gland Lymphadenomas,Sebaceous Lymphadenomas,Cancer of the Salivary Gland,Neoplasms, Salivary Gland,Cancer, Salivary Gland,Cancers, Salivary Gland,Gland Neoplasm, Salivary,Gland Neoplasms, Salivary,Lymphadenoma, Non-Sebaceous,Lymphadenoma, Salivary Gland,Lymphadenoma, Sebaceous,Lymphadenomas, Non-Sebaceous,Lymphadenomas, Salivary Gland,Lymphadenomas, Sebaceous,Neoplasm, Salivary Gland,Non Sebaceous Lymphadenomas,Non-Sebaceous Lymphadenoma,Salivary Gland Cancers,Salivary Gland Lymphadenoma,Salivary Gland Neoplasm,Sebaceous Lymphadenoma
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control

Related Publications

Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
February 2022, Ear, nose, & throat journal,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
February 2016, Otolaryngologia polska = The Polish otolaryngology,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
September 2018, Oral oncology,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
March 2010, Head and neck pathology,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
July 2021, Orbit (Amsterdam, Netherlands),
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
October 2022, Oral oncology,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
January 2019, American journal of otolaryngology,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
May 2011, Medicina oral, patologia oral y cirugia bucal,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
January 2010, Journal of cancer epidemiology,
Linda X Yin, and Kathryn M Van Abel, and Steven A Rooker, and Alex A Nagelschneider, and Kerry D Olsen, and Daniel L Price, and Jeffrey R Janus, and Jan L Kasperbauer, and Eric J Moore
April 2010, Expert opinion on investigational drugs,
Copied contents to your clipboard!