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The blast stem cells of acute myeloblastic leukemia (AML) respond in cell culture to growth factors by both self-renewal and terminal divisions. Both of these functions have been shown to be stimulated by the recombinant growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). In this paper, recombinant gibbon interleukin-3 (IL-3), homologous to human IL-3, was tested on blast cells and compared with the effects of GM-CSF, G-CSF, and medium conditioned by the bladder cell line 5637 (5637-CM). We found that IL-3 was an effective stimulator of blast renewal and terminal divisions. However, great patient-to-patient variation was found. A graphic method of presenting complex comparisons between growth factors is also included.
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
January 1988,
Leukemia research,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
July 1986,
Blood,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
January 1990,
Leukemia & lymphoma,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
January 1989,
Experimental hematology,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
June 1991,
British journal of haematology,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
November 1988,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
April 1988,
Leukemia,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
June 1987,
Blood,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
August 1987,
Leukemia,
J Miyauchi, and
C A Kelleher, and
Y C Yang, and
G G Wong, and
S C Clark, and
M D Minden, and
S Minkin, and
E A McCulloch
May 1986,
Blood,
