Biomaterial Database

[Wound healing models for studying the formation of granulation tissue]. 1987

H P Dinges, and H Redl

In this report models of granulation tissue formation during wound healing are reviewed. As suggested by Kovac and Rudas a distinction is made between inflammatory, foreign body and reparative granulation tissue formation. The advantages and disadvantages of the different models are discussed. While the older studies mainly compared qualitative evaluation of granulation tissue, in recent experiments models involving predominantly quantitative histological and biochemical methods are of increasing importance. One of these is a spongiosa implant model designed by our group which is briefly discussed.

UI	MeSH Term	Description	Entries
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005549	Foreign-Body Reaction	Chronic inflammation and granuloma formation around irritating foreign bodies.	Foreign Body Reaction,Reaction, Foreign-Body
D006097	Granulation Tissue	A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.	Granulation Tissues,Tissue, Granulation,Tissues, Granulation
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings
D014946	Wound Infection	Invasion of a wound by pathogenic microorganisms.	Infection, Wound,Infections, Wound,Wound Infections