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The relation of body fat distribution to plasma levels of glucose and insulin during an oral glucose tolerance test was examined in 355 Black and White school-age children. Both central and peripheral fat were similarly related to fasting, 30-min, and 1-h glucose. Unlike peripheral fat, central body fat was more strongly related to the 1-h insulin response (r = 0.35 vs 0.26); this association remained significant for central fat independent of peripheral fat (r = 0.18). The strong relation of central fat to insulin response was noted in both races and sexes but not in either sexually immature or relatively thin children. These findings indicate that, even in early life, a central body fat pattern relates positively to insulin response to glucose load. Thus, knowledge of body fat localization may help identify persons most susceptible to hyperinsulinemia in early life.
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
July 1999,
Metabolism: clinical and experimental,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
March 1987,
Hypertension (Dallas, Tex. : 1979),
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
September 1988,
The American journal of clinical nutrition,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
October 1996,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
July 1997,
American journal of hypertension,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
December 1989,
Metabolism: clinical and experimental,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
April 1999,
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
March 1992,
Preventive medicine,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
February 1995,
Circulation,
D S Freedman, and
S R Srinivasan, and
G L Burke, and
C L Shear, and
C G Smoak, and
D W Harsha, and
L S Webber, and
G S Berenson
December 1992,
Arteriosclerosis and thrombosis : a journal of vascular biology,
