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Experimental chemotherapy with cisplatin and carboplatin was performed against nine human tumor xenografts serially transplanted into nude mice. Tumors used for the experiment were seven gastric (St-4, St-15, St-40, H-111, SC-2-JCK, SC-6-JCK and Exp-4), one breast (MX-1) and one colon (Co-4) carcinomas. Cisplatin 9 mg/kg and carboplatin 100 mg/kg were administered intraperitoneally (ip). Carboplatin 25 mg/kg was also given ip 4 times every 4 days. The efficacy rates of cisplatin and carboplatin by bolus injection were 77.8% and 66.7% respectively with no statistically significant differences. However, carboplatin was found more effective when given by bolus. The antitumor spectra of both drugs were similar. From these results, these two platinum compounds seemed to be effective against human gastric carcinomas.
Y Shimoyama, and
T Kubota, and
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Anticancer research,
Y Shimoyama, and
T Kubota, and
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M Kuzuoka, and
T Ohishi, and
S Oka, and
S Kikuyama, and
K Ishibiki, and
O Abe
February 1997,
Journal of surgical oncology,
Y Shimoyama, and
T Kubota, and
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O Abe
January 1994,
Anticancer research,
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T Kubota, and
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O Abe
January 1994,
Anticancer research,
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T Kubota, and
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M Kuzuoka, and
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S Kikuyama, and
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O Abe
November 1988,
Nihon Sanka Fujinka Gakkai zasshi,
Y Shimoyama, and
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K Ishibiki, and
O Abe
August 1990,
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Y Shimoyama, and
T Kubota, and
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M Kuzuoka, and
T Ohishi, and
S Oka, and
S Kikuyama, and
K Ishibiki, and
O Abe
January 1987,
The Japanese journal of surgery,
Y Shimoyama, and
T Kubota, and
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M Kuzuoka, and
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O Abe
July 1984,
Nihon Geka Gakkai zasshi,
Y Shimoyama, and
T Kubota, and
S Inoue, and
M Kuzuoka, and
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K Ishibiki, and
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January 1992,
Anticancer research,
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September 1989,
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