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The antiepileptic drugs phenobarbital and phenytoin were determined in serum by enzyme immunoassay (Emit, Syva Corp.) and gas-liquid chromatography. The Emit assays were mechanized by the use of an Eppendorf analyzer 5010. The precision of the Emit system was sufficient (coefficient of variation within series 6-13% and from day to day 8-15% with various calibrators and control sera). Moreover the Emit method is rapid, specific and easy to perform. The procedure requires only 10 microliter of serum per determination. A disadvantage however is the high cost of the reagents. A comparison of the results obtained by Emit and gas-liquid chromatography in a series of about 50 patients showed a good correlation between both methods (correlation coefficient r = 0.968 for phenobarbital and 0.978 for phenytoin).
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
March 1980,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
January 1980,
Clinica chimica acta; international journal of clinical chemistry,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
May 1979,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
January 1984,
Therapeutic drug monitoring,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
April 1984,
Chemical & pharmaceutical bulletin,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
January 2003,
Arzneimittel-Forschung,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
January 1983,
Annals of clinical and laboratory science,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
April 1980,
Journal of chromatography,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
April 1978,
Clinical chemistry,
M Oellerich, and
W R Külpmann, and
R Haeckel, and
R Heyer
January 1988,
Therapeutic drug monitoring,
