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A solid phase sandwich assay for human renin was used to determine the total renin concentration in plasma throughout the course of a normal pregnancy. These values were compared with the enzymatic activity of renin, with and without trypsin treatment. Plasma concentration of immunoreactive renin rapidly increased four fold from 214 +/- 33 pg/ml (in non-pregnant subjects) within a few weeks after conception and remained high up to the third trimester. Total renin concentration, estimated by trypsin-activated enzyme activity showed similar changes, both qualitatively and quantitatively. A positive correlation (r = 0.63, p less than 0.001) between immunoreactive renin concentration and its enzymatic activity was noted whereas the active renin concentration did not positively correlate with the immunoreactive renin concentration. These data indicate that solid phase sandwich assay for human renin should be a pertinent tool to elucidate the role of the renin-angiotensin system in pregnancy.
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
March 1968,
The Journal of clinical endocrinology and metabolism,
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
January 1976,
Nihon rinsho. Japanese journal of clinical medicine,
K Miura, and
T Yukimura, and
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N Nakamura, and
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K Yamamoto
December 1967,
Schweizerische medizinische Wochenschrift,
K Miura, and
T Yukimura, and
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N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
August 1977,
Nihon rinsho. Japanese journal of clinical medicine,
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
January 1966,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
August 1966,
The Journal of endocrinology,
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
December 1965,
Lancet (London, England),
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
May 1974,
The Journal of laboratory and clinical medicine,
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
January 1978,
International pharmacopsychiatry,
K Miura, and
T Yukimura, and
H Yamada, and
N Nakamura, and
K Ito, and
F Ikemoto, and
S Ogita, and
K Yamamoto
June 1966,
The Journal of obstetrics and gynaecology of the British Commonwealth,
