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A case of pulmonary fibrosis attributed to amiodarone was studied immunologically and morphologically. A specific antibody of the IgG class was identified in the serum of this patient which reacted with the patient's own lung tissue. The immunoglobulin did not react with normal lung tissue nor was there evidence of reaction with lung tissue from patients with pulmonary fibrosis but without a history of amiodarone therapy. The patient probably developed a humoral antibody response to a lung-amiodarone complex with the amiodarone acting as a hapten which bound in vivo to the lung tissue. The subsequent antibody-antigen reaction stimulated a proliferation of pulmonary fibroblasts and probably enhanced the fibro-collagen deposition in the lung.
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
September 1984,
Tropical and geographical medicine,
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
January 1984,
Chest,
K Fan, and
R Bell, and
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J Fullenwider
September 1982,
British medical journal (Clinical research ed.),
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
January 1997,
Orvosi hetilap,
K Fan, and
R Bell, and
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J Fullenwider
August 1996,
Orvosi hetilap,
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
January 1983,
European journal of clinical pharmacology,
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
January 1985,
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K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
January 1984,
Revista espanola de cardiologia,
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
October 2000,
Intensive care medicine,
K Fan, and
R Bell, and
S Eudy, and
J Fullenwider
September 1985,
Journal of the American Academy of Dermatology,
