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Despite suggestive evidence from studies on experimental pathology and cell biology of the arterial wall and from clinical and epidemiological studies on non-diabetic subjects indicating that hyperinsulinaemia might be associated with an increased risk of atherosclerotic vascular disease (ASVD) information concerning the role of hyperinsulinaemia as a risk factor of ASVD in diabetic patients still is circumstantial. A few cross-sectional and still fewer prospective studies in patients with non-insulin-dependent diabetes (NIDDM), including two ongoing studies carried out by our own research group, have shown associations between hyperinsulinaemia and the occurrence of ASVD, but these data still are far from consistent and conclusive. Further studies applying combined clinical and epidemiological approach, building upon the results of experimental research concerning possible mechanisms, are needed for better clarification of the role of hyperinsulinaemia as a risk factor of ASVD in NIDDM.
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
March 1997,
European journal of clinical investigation,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
May 1991,
Diabete & metabolisme,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
November 1990,
Clinics in geriatric medicine,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
January 1997,
Journal of diabetes and its complications,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
August 1996,
Annals of medicine,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
December 1997,
Indian journal of medical sciences,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
June 1997,
Diabetic medicine : a journal of the British Diabetic Association,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
September 1988,
Diabetes research and clinical practice,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
January 1988,
Indian journal of public health,
K Pyörälä, and
M Uusitupa, and
M Laakso, and
O Siitonen, and
L Niskanen, and
T Rönnemaa
June 1992,
Diabetologia,
