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T lymphocytes purified from lymph nodes and spleens of chancre-immune, inbred strain 2 guinea pigs, when infused into syngeneic guinea pigs, conferred protection against challenge with Treponema pallidum subsp. pallidum Nichols. No protection was conferred by similar injections of cell suspensions from normal guinea pigs or guinea pigs immunized with T. phagedenis biotype Reiter or T. pallidum-free testis supernatants from infected rabbits. Similar results were obtained with homozygous C4D guinea pigs. After several months of infection, 2 of 11 strain 2 and 1 of 8 strain C4D recipients of T. pallidum-immune cells developed an erythematous reaction of short duration at the injection site; 2 of these recipients were positive for T. pallidum. Throughout the experimental period the humoral response to treponemal antigens was substantially lower in the adoptively immune guinea pigs than in various unprotected control groups. Passive immunity to infection with T. pallidum, however, seems to be dose related, since asymptomatic infection persisted for as long as 3 months after challenge in strain 2 guinea pigs transfused with 10(8) T. pallidum-immune lymphocytes, but not in C4D recipients of twice as many immune cells.
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
October 1985,
Journal of immunology (Baltimore, Md. : 1950),
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
December 1976,
Journal of the American Venereal Disease Association,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
January 1957,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
May 1970,
Klinische Wochenschrift,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
March 2006,
Infection and immunity,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
June 1979,
Infection and immunity,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
January 1966,
Dermatologica,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
April 1985,
Genitourinary medicine,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
January 1988,
Infection and immunity,
V Wicher, and
K Wicher, and
A Jakubowski, and
S M Nakeeb
September 1985,
Journal of the National Cancer Institute,
