Assessment of pulmonary toxicity of potential antioxidant drug PEGylated nanoceria after intratracheal instillation in rats. 2021

Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, China.

Cerium oxide (CeO2 ) nanoparticles have unique redox properties and exert excellent antioxidant effects in the biological environment. In recent years, many researchers have focused on the CeO2 nanoparticles as an effective antioxidant drug in the prevention and treatment of various diseases. However, the toxicity of CeO2 nanoparticles in vivo remains controversial and still needs intensive research. Therefore, the objective of this study is to investigate the pulmonary and systemic toxicity in rats after 14 days of exposure to the PEGylated CeO2 nanoparticles (abbreviated as CNPs; exposure dose of 2, 10, or 20 mg/kg) through a single intratracheal instillation (IT). We assessed the indicators of lung injury and the pathological damage degree of lung tissue. The bronchoalveolar lavage fluid (BALF) analysis and lung histopathology revealed the occurrence of slight pulmonary inflammation in the 20-mg/kg experimental group rats. However, the inflammation factors in the lung tissue of every group rats did not significantly increase, and the levels of superoxide dismutase (SOD) and glutathione (GSH) in lung tissue homogenate rose considerably in the experimental groups. Collectively, these results indicated that pulmonary exposure by the high dose of CNPs could induce mild pulmonary inflammation but did not cause severe systemic toxicity. Moreover, we speculate that the mechanism of pulmonary toxicity of CNPs in rats was due to the autophagic death of healthy lung epithelial cells mediated by endoplasmic reticulum stress. Our results implicate that CNPs can be safely used as an antioxidant drug for the oxidative stress pulmonary diseases.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008171 Lung Diseases Pathological processes involving any part of the LUNG. Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D008297 Male Males
D011014 Pneumonia Infection of the lung often accompanied by inflammation. Experimental Lung Inflammation,Lobar Pneumonia,Lung Inflammation,Pneumonia, Lobar,Pneumonitis,Pulmonary Inflammation,Experimental Lung Inflammations,Inflammation, Experimental Lung,Inflammation, Lung,Inflammation, Pulmonary,Inflammations, Lung,Inflammations, Pulmonary,Lobar Pneumonias,Lung Inflammation, Experimental,Lung Inflammations,Lung Inflammations, Experimental,Pneumonias,Pneumonias, Lobar,Pneumonitides,Pulmonary Inflammations
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D001992 Bronchoalveolar Lavage Fluid Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung. Alveolar Lavage Fluid,Bronchial Lavage Fluid,Lung Lavage Fluid,Bronchial Alveolar Lavage Fluid,Lavage Fluid, Bronchial,Lavage Fluid, Lung,Pulmonary Lavage Fluid,Alveolar Lavage Fluids,Bronchial Lavage Fluids,Bronchoalveolar Lavage Fluids,Lavage Fluid, Alveolar,Lavage Fluid, Bronchoalveolar,Lavage Fluid, Pulmonary,Lavage Fluids, Alveolar,Lavage Fluids, Bronchial,Lavage Fluids, Bronchoalveolar,Lavage Fluids, Lung,Lavage Fluids, Pulmonary,Lung Lavage Fluids,Pulmonary Lavage Fluids
D002563 Cerium An element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.
D004364 Pharmaceutical Preparations Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form. Drug,Drugs,Pharmaceutical,Pharmaceutical Preparation,Pharmaceutical Product,Pharmaceutic Preparations,Pharmaceutical Products,Pharmaceuticals,Preparations, Pharmaceutical,Preparation, Pharmaceutical,Preparations, Pharmaceutic,Product, Pharmaceutical,Products, Pharmaceutical
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
January 2013, The Journal of toxicological sciences,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
March 2012, Environmental toxicology,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
January 2022, Human & experimental toxicology,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
October 2022, Toxicological research,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
April 1993, Pediatric research,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
October 2013, Journal of nanoscience and nanotechnology,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
January 2017, The Journal of toxicological sciences,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
October 2016, Inhalation toxicology,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
April 2017, Biomedical and environmental sciences : BES,
Qinqing Qian, and Yun Zhang, and Yuan Chen, and Chenqiao Ye, and Qiang Feng, and Jinqing Tu, and Zhenbo Lu, and Yilan Xu, and Na Ran, and Guiying Xing, and Zhangsen Yu
September 2017, Inhalation toxicology,
Copied contents to your clipboard!