Comprehensive evaluation of differentially expressed non-coding RNAs identified during macrophage activation. 2020

Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
Basic Research Laboratory for Vascular Remodeling, Chonnam National University Medical School, Jeollanam-do, Republic of Korea; Department of Biochemistry, Chonnam National University Medical School, Jeollanam-do, Republic of Korea. Electronic address: ykk@jnu.ac.kr.

Macrophages are the primary cell type in the immune system and are activated in response to diverse external stimuli. They can exert inflammatory or anti-inflammatory responses depending on the type of stimuli in the system, and as such rely on a complex network of diverse signaling pathways to function. Non-coding RNAs have recently been established as an important class of regulators linked to the activation of macrophages. Although the roles of many microRNAs have been described, the majority of the other types of regulatory non-coding RNAs, including long non-coding RNAs (lncRNAs), remain undefined. In this study, we performed a comprehensive analysis of several large RNA sequencing datasets to identify common lncRNAs differentially expressed after M1 or M2 macrophage induction. We identified the lncRNAs that underwent significant changes in each dataset and established a list of commonly altered lncRNAs. We expect that our data will act as a valuable resource for future studies designed to uncover the roles of these lncRNAs in determining macrophage fates.

UI MeSH Term Description Entries
D008262 Macrophage Activation The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants. Activation, Macrophage,Activations, Macrophage,Macrophage Activations
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000067996 RAW 264.7 Cells A transformed macrophage cell line isolated from ASCITES of mice infected with ABELSON MURINE LEUKEMIA VIRUS. RAW 264.7 Cell Line,264.7 Cell, RAW,264.7 Cells, RAW,Cell, RAW 264.7,Cells, RAW 264.7,RAW 264.7 Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D053263 Gene Regulatory Networks Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations. Gene Circuits,Gene Modules,Gene Networks,Transcriptional Networks,Gene Module,Circuit, Gene,Circuits, Gene,Gene Circuit,Gene Network,Gene Regulatory Network,Module, Gene,Modules, Gene,Network, Gene,Network, Gene Regulatory,Network, Transcriptional,Networks, Gene,Networks, Gene Regulatory,Networks, Transcriptional,Regulatory Network, Gene,Regulatory Networks, Gene,Transcriptional Network
D062085 RNA, Long Noncoding A class of untranslated RNA molecules that are typically greater than 200 nucleotides in length and do not code for proteins. Members of this class have been found to play roles in transcriptional regulation, post-transcriptional processing, CHROMATIN REMODELING, and in the epigenetic control of chromatin. LincRNA,RNA, Long Untranslated,LINC RNA,LincRNAs,Long Intergenic Non-Protein Coding RNA,Long Non-Coding RNA,Long Non-Protein-Coding RNA,Long Noncoding RNA,Long ncRNA,Long ncRNAs,RNA, Long Non-Translated,lncRNA,Long Intergenic Non Protein Coding RNA,Long Non Coding RNA,Long Non Protein Coding RNA,Long Non-Translated RNA,Long Untranslated RNA,Non-Coding RNA, Long,Non-Protein-Coding RNA, Long,Non-Translated RNA, Long,Noncoding RNA, Long,RNA, Long Non Translated,RNA, Long Non-Coding,RNA, Long Non-Protein-Coding,Untranslated RNA, Long,ncRNA, Long,ncRNAs, Long
D020869 Gene Expression Profiling The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell. Gene Expression Analysis,Gene Expression Pattern Analysis,Transcript Expression Analysis,Transcriptome Profiling,Transcriptomics,mRNA Differential Display,Gene Expression Monitoring,Transcriptome Analysis,Analyses, Gene Expression,Analyses, Transcript Expression,Analyses, Transcriptome,Analysis, Gene Expression,Analysis, Transcript Expression,Analysis, Transcriptome,Differential Display, mRNA,Differential Displays, mRNA,Expression Analyses, Gene,Expression Analysis, Gene,Gene Expression Analyses,Gene Expression Monitorings,Gene Expression Profilings,Monitoring, Gene Expression,Monitorings, Gene Expression,Profiling, Gene Expression,Profiling, Transcriptome,Profilings, Gene Expression,Profilings, Transcriptome,Transcript Expression Analyses,Transcriptome Analyses,Transcriptome Profilings,mRNA Differential Displays

Related Publications

Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
August 2019, Oncology letters,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
May 2019, Gene,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
January 2016, Scientific reports,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
January 2018, American journal of translational research,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
December 2015, Genomics data,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
September 2023, Heliyon,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
January 2019, Zhonghua nan ke xue = National journal of andrology,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
January 2020, Frontiers in physiology,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
July 2012, Nucleic acids research,
Young-Kook Kim, and Yong Sook Kim, and Sojeong Kim, and Yoo Jin Kim, and Youngkeun Ahn, and Hyun Kook
May 2024, Archives of microbiology,
Copied contents to your clipboard!