In-vitro dewetting properties of planned replacement and daily disposable silicone hydrogel contact lenses. 2021

Erol Havuz, and Onur Gokmen
Health Sciences University Samsun Training and Research Hospital, Department of Ophthalmology Samsun, Turkey.

To compare the in-vitro videokeratoscopic surface dewetting properties of new-generation silicone hydrogel (SiH) planned replacement contact lenses (CL) with those of daily disposable CLs. A chrome coated cornea model was used for the in-vitro evaluation of surface dewetting. Pre-lens and post-lens film layers were formed by instilling a normal preservative-free normal saline solution (PFNs) (0.9 %) before and after the placement of the CL on the model cornea. The tests were carried out on fanfilcon A, lotrafilcon B, samfilcon A, and senofilcon A lenses, as well as such daily disposable lenses as delefilcon, nesofilcon A and senofilcon one day. Using videokeratoscopic methods, images were obtained at 30-second intervals up to 180 s in the lens and control groups and were analyzed by the ImajeJĀ® program. The mean measured area of the keratoscopic rings was largest in the fanfilcon group (67.56 mm2), followed by 61.53 mm2 in the lotrafilcon A group and 64.60 mm2 in the samfilcon group, while the smallest area was measured in the senofilcon A group, at 56.90 mm2. The area was measured as 64.33, 63.09 and 68.39 mm2 for the delefilcon, nesofilcon and Senofilcon one day CLs, respectively. The dewetting patterns and properties differed in the CL groups (p < 0.05), while no significant differences were found between the measured areas of the planned replacement and daily disposable CL groups (p > 0.05). Videokeratoscopy using in-vitro cornea models has been identified as a reproducible and reliable method for the analysis of the surface dewetting of CLs. The dewetting characteristics of CL groups have been found to differ from each other, despite all being produced from SiH materials. The surface wetting coating has been shown to affect CL dewetting performance.

UI MeSH Term Description Entries
D003263 Contact Lenses, Hydrophilic Soft, supple contact lenses made of plastic polymers which interact readily with water molecules. Many types are available, including continuous and extended-wear versions, which are gas-permeable and easily sterilized. Lenses, Contact, Hydrophilic,Soft Contact Lenses,Hydrophilic Contact Lens,Soft Contact Lens,Contact Lens, Hydrophilic,Contact Lens, Soft,Contact Lenses, Soft,Hydrophilic Contact Lenses,Lens, Hydrophilic Contact,Lens, Soft Contact,Lenses, Hydrophilic Contact,Lenses, Soft Contact
D004209 Disposable Equipment Apparatus, devices, or supplies intended for one-time or temporary use. Equipment, Disposable
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012828 Silicones A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed) Silicone
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property
D017155 Wettability The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid. Hygroscopicity,Wetability,Hygroscopicities,Wetabilities,Wettabilities
D020100 Hydrogels Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed) Hydrogel,In Situ Hydrogel,In Situ Hydrogels,Patterned Hydrogel,Patterned Hydrogels,Hydrogel, In Situ,Hydrogel, Patterned

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