BIOMAT Database Logo BIOMAT Database Logo

Deuterium isotope effect in the activation of nitrosomorpholine into a bacterial mutagen. 1977

G Charnley, and M C Archer

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D009025 Morpholines Tetrahydro-1,4-Oxazines,Tetrahydro 1,4 Oxazines
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D009602 Nitrosamines A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties. Nitrosamine
D009603 Nitroso Compounds Organic compounds containing the nitroso (-N Compounds, Nitroso
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

G Charnley, and M C Archer
Activation of nitrosomorpholine and nitrosopyrrolidine to bacterial mutagens.
July 1974, Mutation research,
G Charnley, and M C Archer
On the metabolic activation of N-nitrosomorpholine and N'-nitrosonornicotine: effects of deuterium substitution.
January 1982, IARC scientific publications,
G Charnley, and M C Archer
Deuterium isotope effect in chloramphenicol action.
October 1971, Journal of medicinal chemistry,
G Charnley, and M C Archer
Deuterium isotope effect on carbon isotope fractionation in photosynthesis.
January 1967, Science (New York, N.Y.),
G Charnley, and M C Archer
Kinetic deuterium isotope effects in glucocorticoid receptor activation.
January 1984, Journal of receptor research,
G Charnley, and M C Archer
A steric deuterium isotope effect in 1,1,3,3-tetramethylcyclohexane.
August 2007, Journal of the American Chemical Society,
G Charnley, and M C Archer
Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.
October 1976, Journal of the National Cancer Institute,
G Charnley, and M C Archer
Natulan, a bacterial mutagen requiring complex mammalian metabolic activation.
April 1980, Mutation research,
G Charnley, and M C Archer
Deuterium Isotope Effect on the Dissociation of Weak Acids in Water and Deuterium Oxide.
January 1969, Journal of research of the National Bureau of Standards. Section A, Physics and chemistry,
G Charnley, and M C Archer
Deuterium kinetic isotope effects and the mechanism of the bacterial luciferase reaction.
February 1998, Biochemistry,
Copied contents to your clipboard!