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The renal elimination of the weak-base cimetidine was studied in five healthy male subjects during normal and restricted (low-protein, low-calorie) diets in a randomized crossover fashion. An intravenous dose of cimetidine, 7 mg/kg, was administered on day 7 of the normal (100 gm/70 kg protein/day) and the restricted (19 gm/70 kg protein/day) diets. The renal clearance of cimetidine was unchanged by the dietary restriction; however, the fractional excretion of cimetidine increased from 3.06 to 3.94 (P less than 0.05), indicating an apparent increase in net tubular secretion of cimetidine during the restricted diet. We conclude that cimetidine dosage adjustments are apparently not necessary for patients with acutely restricted nutrient intake, although other weakly acidic and basic drugs may require dosage changes.
L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
June 2015,
American journal of physiology. Renal physiology,
L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
April 1989,
Clinical pharmacology and therapeutics,
L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
December 1989,
Seminars in nephrology,
L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
May 2023,
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L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
October 1990,
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L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
September 1980,
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L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
October 1986,
Clinical pharmacology and therapeutics,
L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
May 1976,
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L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
January 1994,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
L M Gersema, and
G D Park, and
T M Kitt, and
R Spector
January 1997,
Mineral and electrolyte metabolism,
