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Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study. 2020
Takashi Tamura, and
Nagato Kuriyama, and
Teruhide Koyama, and
Etsuko Ozaki, and
Daisuke Matsui, and
Yuka Kadomatsu, and
Mineko Tsukamoto, and
Yoko Kubo, and
Rieko Okada, and
Asahi Hishida, and
Tae Sasakabe, and
Sayo Kawai, and
Mariko Naito, and
Naoyuki Takashima, and
Aya Kadota, and
Keitaro Tanaka, and
Megumi Hara, and
Sadao Suzuki, and
Hiroko Nakagawa-Senda, and
Toshiro Takezaki, and
Ippei Shimoshikiryo, and
Hiroaki Ikezaki, and
Masayuki Murata, and
Isao Oze, and
Hidemi Ito, and
Haruo Mikami, and
Yohko Nakamura, and
Kiyonori Kuriki, and
Kokichi Arisawa, and
Hirokazu Uemura, and
Kenji Takeuchi, and
Kenji Wakai
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. ttamura@med.nagoya-u.ac.jp.
There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.
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