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Each of more than 30 monoclonal antibodies that had been raised against Mycobacterium leprae and previously classified as reactive with carbohydrate was shown to be directed against lipoarabinomannan, a prominent, highly pervasive, myo-inositol-phosphate-containing, cross-reactive antigen within the leprosy bacillus. Some of the antibodies preferentially bound to the lipopolysaccharide of M. leprae rather than to that of Mycobacterium tuberculosis, suggesting the presence of distinguishing structural features. The presence of alkali-labile inositol 1-phosphate in the lipopolysaccharide from M. tuberculosis and its apparent absence from the M. leprae product may account for the difference.
H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
August 1992,
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H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
July 1985,
Infection and immunity,
H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
March 1990,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
November 1992,
Zhonghua yi xue za zhi,
H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
July 1982,
Infection and immunity,
H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
February 1987,
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H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
May 1989,
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H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
June 1983,
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H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
August 1994,
Hybridoma,
H Gaylord, and
P J Brennan, and
D B Young, and
T M Buchanan
December 1986,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
