The purpose of the study was to evaluate the functional resistance of enamel in children with malocclusions. Material and research methods: there were examined 579 children aged 12-16 years with malocclusions and was determined the functional enamel resistance. The data obtained in the study indicate that the prevalence of malocclusions among examined children, according to the average data, is 67,76±1,99%. There is a tendency to decrease the number of persons with orthodontic pathology with the age among the examined group of children. It was found that from 12 to 16 years the prevalence of malocclusions decreases from 71,5±4,47% to 64,17±4,38%, р>0,05. The lowest prevalence of malocclusions is found in the group of 16-year-old children. From 12 to 13 years the prevalence of malocclusions decreases by 3,43%, from 13 to 14 years - by 2,49%, from 14 to 15 years increases by 0,72%, and by 16 years decreases by 5,38%. The decrease in the prevalence of malocclusions in the group of examined children with age is explained by the increase in the number of persons who were orthodontic treated and were good motivated to improve their aesthetic appearance. Among children with caries resistant enamel (CR) 35,22±2,48% of persons were revealed with malocclusions and 51,97±3,75% - without malocclusions, (р<0,01), among children with reduced enamel resistance (RR) and caries susceptible enamel (CS) - 64,78±2,48% and 48,03±3,75%, respectively, p<0,01. Among children with CR enamel from 12 to 16 years, the number of persons with malocclusions decreases by 16,14% (from 35,62±5,60% to 29,87±5,22%), and among children with RR and CS enamel - increases by 8,93% (from 64,38±5,60% to 70,13±5,22%). In children without malocclusions there are no clear trends, regardless of the enamel resistance level. It was found that among all children with crowding 30,00±3,42% persons had caries-resistant enamel, and in 70,00±3,42% of children the enamel was reduced resistant or caries-susceptible, р<0,001. Thus, the results of the study showed that in children with CR enamel, malocclusions are much more common than in chidren with RR and CS enamel. In children with CS enamel, the enamel structure is resolved, which can be caused by a violation of the mineral metabolism, especially during the period of development and formation of the body. Against the background of such disorders, there may be susceptibility to the development of dental caries and malocclusions, which is important to consider when carrying out preventive measures.