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A therapeutic trial with azathioprine and steroids has been carried out on a group of definite MS subjects. Such pharmacologic association was suggested by many observations pointing out the possibility of balancing the adverse effects of azathioprine by steroid administration. The therapeutic protocol included an alternate administration of azathioprine 2 mg/Kg/die for 15 consecutive days, followed by triamcinolone 40 mg IM in a single dose during the following 15 days. The patient population was composed of 34 subjects, 7 of which showed a RR course, 15 a RP form and 12 a CP course. Our results showed that this treatment appeared particularly useful in RP forms; it could also be indicated in CP forms, at the beginning of chronic progression.
V Floris, and
M Spadaro, and
G Tilia
January 1988,
Bulletin of the Institute of Maritime and Tropical Medicine in Gdynia,
V Floris, and
M Spadaro, and
G Tilia
January 1985,
La Sante publique,
V Floris, and
M Spadaro, and
G Tilia
April 1964,
The Practitioner,
V Floris, and
M Spadaro, and
G Tilia
November 1981,
Acta neurologica Scandinavica,
V Floris, and
M Spadaro, and
G Tilia
January 1973,
Revue roumaine de virologie,
V Floris, and
M Spadaro, and
G Tilia
October 1985,
Journal of biological response modifiers,
V Floris, and
M Spadaro, and
G Tilia
August 1987,
Archives of neurology,
V Floris, and
M Spadaro, and
G Tilia
November 1983,
Annals of neurology,
V Floris, and
M Spadaro, and
G Tilia
April 1962,
Munchener medizinische Wochenschrift (1950),
V Floris, and
M Spadaro, and
G Tilia
September 1973,
Revue de neuropsychiatrie infantile et d'hygiene mentale de l'enfance,
