BIOMAT Database Logo BIOMAT Database Logo

Biliary cast syndrome after liver transplantation: A cholangiographic evolution study. 2021

Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Erasmus Hospital, ULB (Free University of Brussels), Brussels, Belgium.

OBJECTIVE The aim of this study is to describe the cholangiographic features and endoscopic management of biliary cast syndrome (BCS), a rare specific ischemic cholangiopathy following liver transplantation. METHODS Patients with biliary complications were identified from prospectively collected database records of patients who underwent liver transplantation at the Erasme Hospital from January 2005 to December 2014. After excluding patients with hepatico-jejunostomy or no suspicion of stricture, cholangiograms obtained during endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance imaging were systematically reviewed. Biliary complications were categorized as anastomotic (AS) and non-AS strictures, and patients with BCS were identified. Clinical, radiological, and endoscopic data were reviewed. RESULTS Out of 311 liver transplantations, 14 cases were identified with BCS (4.5%) and treated with ERCP. Intraductal hyperintense signal on T1-weighted magnetic resonance and a "duct-in-a-duct" image were the most frequent features of BCS on magnetic resonance imaging. On initial ERCP, 57% of patients had no stricture. Complete cast extraction was achieved in 12/14, and one of these had cast recurrence. On follow-up, 85% of the patients developed biliary strictures that were treated with multiple plastic stents reaching 60% complete stricture resolution, but 40% of them had recurrence. After a median follow-up of 58 months, BCS patients had lower overall and graft survival (42.9% and 42.9%) compared with non-AS (68.8% and 56.3%) and AS (83.3% and 80.6%), respectively. CONCLUSIONS Particular magnetic resonance-cholangiographic and ERCP-cholangiographic features of BCS have been identified. Outcomes for BCS are characterized by high complete cast extraction rates, high incidence of secondary strictures, and poorer prognosis.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002758 Cholangiography An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken. Cholangiographies
D002760 Cholangiopancreatography, Endoscopic Retrograde Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure. ERCP,Endoscopic Retrograde Cholangiopancreatography,Retrograde Cholangiopancreatography, Endoscopic,Cholangiopancreatographies, Endoscopic Retrograde,Endoscopic Retrograde Cholangiopancreatographies,Retrograde Cholangiopancreatographies, Endoscopic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Biliary cast syndrome after liver transplantation.
November 2012, ANZ journal of surgery,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
[A case of biliary cast syndrome after cadaveric liver transplantation].
February 2007, The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
A biliary cast syndrome requiring liver transplantation: an original sequence.
December 2023, Journal of gastrointestinal and liver diseases : JGLD,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Biliary cast syndrome and liver abscesses complicating composite multivisceral transplantation.
January 2014, Endoscopy,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Biliary cast syndrome post-liver transplantation: risk factors and outcome.
September 2013, Liver international : official journal of the International Association for the Study of the Liver,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Biliary complications after liver transplantation: addition of T1-weighted images to MR cholangiopancreatography facilitates detection of cast in biliary cast syndrome.
May 2012, Radiology,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Percutaneous treatment of biliary cast syndrome after orthotopic liver transplantation: comparison of mechanical versus hydraulic rheolytic cast extraction.
October 2011, Cardiovascular and interventional radiology,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Biliary cast syndrome following liver transplantation: Predictive factors and clinical outcomes.
October 2008, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
Biliary sludge-cast formation following liver transplantation.
February 1988, Hepato-gastroenterology,
Arnaud Lemmers, and Martina Pezzullo, and Alia Hadefi, and Séverine Dept, and Desislava Germanova, and Thierry Gustot, and Delphine Degré, and Nathalie Boon, and Christophe Moreno, and Daniel Blero, and Marianna Arvanitakis, and Myriam Delhaye, and Alain Vandermeeren, and Hassan Njimi, and Jacques Devière, and Olivier Le Moine, and Valerio Lucidi
[Clinical manifestation and patho-typing of biliary cast syndrome in patients after orthotopic liver transplantation].
May 2008, Zhonghua wai ke za zhi [Chinese journal of surgery],
Copied contents to your clipboard!