Biomaterial Database

Anaplastic lymphoma kinase-negative systemic anaplastic large cell lymphoma with secondary involvement of the breast. 2021

Fumi Miyagawa, and Kohei Ogawa, and Hideo Asada

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001940	Breast	In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.	Breasts
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077548	Anaplastic Lymphoma Kinase	A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.	ALK Kinase,ALK Tyrosine Kinase Receptor,Anaplastic Lymphoma Receptor Tyrosine Kinase,CD246 Antigen,NPM-ALK,Nucleophosmin-Anaplastic Lymphoma Kinase,Nucleophosmin Anaplastic Lymphoma Kinase
D017728	Lymphoma, Large-Cell, Anaplastic	A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.	Anaplastic Large-Cell Lymphoma,CD30-Positive Anaplastic Large-Cell Lymphoma,Lymphoma, Large-Cell, Ki-1,CD30+ Anaplastic Large-Cell Lymphoma,Ki-1 Lymphoma,Systemic Anaplastic Large-Cell Lymphoma,Anaplastic Large Cell Lymphoma,Anaplastic Large-Cell Lymphomas,CD30 Positive Anaplastic Large Cell Lymphoma,CD30+ Anaplastic Large Cell Lymphoma,Ki 1 Lymphoma,Ki-1 Lymphomas,Large-Cell Lymphoma, Anaplastic,Large-Cell Lymphomas, Anaplastic,Lymphoma, Anaplastic Large-Cell,Lymphoma, Ki-1,Lymphomas, Anaplastic Large-Cell,Lymphomas, Ki-1,Systemic Anaplastic Large Cell Lymphoma
D020794	Receptor Protein-Tyrosine Kinases	A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.	PTK Receptor,Receptors, Protein-Tyrosine Kinase,Tyrosine Kinase Linked Receptor,Tyrosine Kinase Linked Receptors,Tyrosine Kinase Receptor,Tyrosine Kinase Receptors,PTK Receptors,Protein-Tyrosine Kinase Receptor,Receptor Protein-Tyrosine Kinase,Kinase Receptor, Tyrosine,Kinase, Receptor Protein-Tyrosine,Kinases, Receptor Protein-Tyrosine,Protein-Tyrosine Kinase Receptors,Protein-Tyrosine Kinase, Receptor,Protein-Tyrosine Kinases, Receptor,Receptor Protein Tyrosine Kinase,Receptor Protein Tyrosine Kinases,Receptor, PTK,Receptor, Protein-Tyrosine Kinase,Receptor, Tyrosine Kinase,Receptors, PTK,Receptors, Protein Tyrosine Kinase