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Using a DNA probe from an avian transforming virus, NK24, that contains the fos gene and that was newly isolated and characterized (M. Nishizawa, N. Goto, and S. Kawai, J. Virol. 61:3733-3740, 1987), we cloned and sequenced the chicken c-fos gene. Results showed that this gene, like the mouse or human c-fos gene, contains four exons encoding a predicted gene product of 367 amino acids which is about 79% homologous to p55c-fos (mouse), excluding several small insertions or gaps. The predicted gene product, however, contains two nonhomologous regions, as suggested by sequence analysis of the NK24 genome. About half the identical amino acids of these gene products are encoded by different codons, and the guanine-plus-cytosine content in the third letter of each codon used in the entire chicken c-fos coding region is high (93%). The 5'-flanking region of the TATA box contains a sequence that is homologous to a putative transcriptional regulatory sequence in the mouse or human c-fos gene. The 3'-noncoding region of chicken c-fos is strikingly homologous to that of mouse or human c-fos and covers a 67-base-pair adenine-plus-thymine-rich stretch which was previously reported to be essential for an inhibitory effect on the expression of the mouse c-fos gene.
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
January 1991,
Gene,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
January 2004,
Marine environmental research,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
March 1991,
Biochemistry international,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
July 1993,
FEMS microbiology letters,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
March 1990,
Biochemical and biophysical research communications,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
June 1995,
Journal of bacteriology,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
December 1994,
Bioscience, biotechnology, and biochemistry,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
August 1988,
Molecular & general genetics : MGG,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
June 1983,
Proceedings of the National Academy of Sciences of the United States of America,
K T Fujiwara, and
K Ashida, and
H Nishina, and
H Iba, and
N Miyajima, and
M Nishizawa, and
S Kawai
June 1985,
Virology,
