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Several lots of a yeast-derived hepatitis B vaccine at different doses and a 20 micrograms dose of plasma-derived vaccine were tested in young healthy adults and compared with respect to risk of hypersensitivity reactions, reactogenicity, and immunogenicity. No signs of hypersensitivity either pre-existing or vaccine-induced were observed. Reactogenicity was low and similar in all vaccine groups. It was not dose related and unaffected by the number of injections. Immunogenicity was evaluated for a 0, 1, 2, and 12 month vaccination schedule. Seroconversion rates (greater than or equal to 10 IU/l) were not significantly different between the purified yeast- and plasma-derived vaccines one month after the second vaccination whereas the percentage of seroconversion was slightly lower in the groups receiving only partly purified recombinant vaccines. Although geometric mean titres induced by the plasma-derived vaccine were somewhat higher after the first months, the antibody titres induced by the recombinant vaccine were at least as high as those elicited by a plasma-derived vaccine following the booster dose.
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
January 1992,
Vaccine,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
November 1988,
Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
January 1989,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
February 1990,
Epidemiology and infection,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
February 1989,
Journal of medical virology,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
January 1991,
Tropical and geographical medicine,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
January 1998,
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
September 1989,
The American journal of medicine,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
October 1990,
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
G Wiedermann, and
F Ambrosch, and
P Kremsner, and
C Kunz, and
P Hauser, and
E Simoen, and
F André, and
A Safary
January 1987,
Postgraduate medical journal,
