[Strains of salmonella with altered antigenic structure]. 1977

L K Stepanova, and N S Sergeeva

The authors studied 260 freshly isolated and laboratory cultures of salmonellae belonging to different serological groups. Heterogeneity of the majority of the strains studied by colour fluorescence of the colonies in the oblique light flux was demonstrated. Genetically bound spontaneous stable mutants with a different antigenic composition were selected by this method from a number of serological types. The isolated mutants were in the S-form and failed to differ by morphological, cultural and biochemical properties from the initial parental strains. A study of the antigenic structure by the method of agar immunoelectrophoresis and determination of their serological properties showed the mutants to have disturbances in the processes of O- or K-antigen synthesis.

UI MeSH Term Description Entries
D007122 Immunoelectrophoresis A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D000942 Antigens, Bacterial Substances elaborated by bacteria that have antigenic activity. Bacterial Antigen,Bacterial Antigens,Antigen, Bacterial
D012475 Salmonella A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.
D012484 Salmonella paratyphi B A serotype of SALMONELLA ENTERICA which is an agent of PARATYPHOID FEVER in humans. Salmonella schottmuelleri,Salmonella enterica serovar Paratyphi B
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species

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