Biomaterial Database

Relationship of Weight Change Patterns From Young to Middle Adulthood With Incident Cardiovascular Diseases. 2021

Mengyi Liu, and Zhuxian Zhang, and Chun Zhou, and Panpan He, and Yuanyuan Zhang, and Huan Li, and Qinqin Li, and Chengzhang Liu, and Binyan Wang, and Jianping Li, and Yan Zhang, and Xin Xu, and Xiaobin Wang, and Xiping Xu, and Yong Huo, and Fan Fan Hou, and Xianhui Qin

Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.

The effect of weight change patterns on cardiovascular diseases (CVD) remains uncertain. We aim to examine the relation of weight change patterns and absolute weight change from young adulthood to midlife with incident CVD. Retrospective cohort study. National Health and Nutrition Examination Survey 1999-2016. A total of 20 715 US adults aged 40 through 79 with recalled weight at young adulthood (25 years) and midlife (10 years before baseline). CVD status was determined by self-report of a prior diagnosis, and age at diagnosis was used to establish time of CVD onset. CVD events was defined as the first occurrence of a congestive heart failure, coronary heart disease, angina pectoris, heart attack, or stroke. After 9.76 years of follow-up, compared with participants who remained at normal weight, those in maximum overweight, changing from nonobese to obese, changing from obese to nonobese, maintaining obesity between young and middle adulthood had a 39% (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.19-1.62), 93% (HR, 1.93; 95% CI, 1.64-2.28), 125% (HR, 2.25; 95% CI, 1.29-3.94), and 132% (HR, 2.32; 95% CI, 1.68-3.20) higher risk of CVD, respectively. In addition, compared with weight change within 2.5 kg, weight gain ≥ 10.0 kg was associated with higher risk of CVD. Both nonobese to obese, obese to nonobese, and stable obese from young to middle adulthood were associated with increased risks of CVD. The findings emphasize the importance of maintaining normal weight throughout the adulthood for preventing CVD in later life.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009749	Nutrition Surveys	A systematic collection of factual data pertaining to the nutritional status of a human population within a given geographic area. Data from these surveys are used in preparing NUTRITION ASSESSMENTS.	NHANES,National Health and Nutrition Examination Survey,Nutritional Surveys,Nutrition Survey,Nutritional Survey,Survey, Nutrition,Survey, Nutritional,Surveys, Nutrition,Surveys, Nutritional
D009765	Obesity	A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002318	Cardiovascular Diseases	Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077962	Body-Weight Trajectory	A general pattern of body weight gain or loss over many years. Weight change trajectory is influenced by several determinants in children and adults.	Weight Change Trajectory,Weight Gain Trajectory,Weight Loss Trajectory,Weight Trajectory,Body Weight Trajectory,Body-Weight Trajectories,Change Trajectories, Weight,Change Trajectory, Weight,Gain Trajectories, Weight,Gain Trajectory, Weight,Loss Trajectories, Weight,Loss Trajectory, Weight,Trajectories, Body-Weight,Trajectories, Weight,Trajectories, Weight Change,Trajectories, Weight Gain,Trajectories, Weight Loss,Trajectory, Body-Weight,Trajectory, Weight,Trajectory, Weight Change,Trajectory, Weight Gain,Trajectory, Weight Loss,Weight Change Trajectories,Weight Gain Trajectories,Weight Loss Trajectories,Weight Trajectories
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults