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The object of the study was to find a model to summarize all the information from dose-response curves, by determining the coefficients to be used to compare groups of subjects. Three coefficients were calculated from the following model: F(d)/F(o) = ONE - k(d-delta)alpha+, where F(d)/F(o) was the ratio between FEV1 at dose (d) of methacholine and prechallenge FEV1, 'k' the slope of the relative variation of FEV1 with the dose, 'delta' the threshold dose and 'alpha' a shape factor. The model was applied to the study of hyperresponsiveness in a population of 317 men. The results illustrated the interest of this model which was applicable to 91% of the population and permitted fine discrimination of the groups studied.
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
January 2021,
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
May 2017,
Scientific reports,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
June 1981,
Radioisotopes,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
May 1994,
The European respiratory journal,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
March 1990,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
January 2020,
Experimental lung research,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
February 1971,
British journal of pharmacology,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
January 2009,
Pharmaceutical statistics,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
January 1980,
Psychopharmacology,
F Neukirch, and
J Maccario, and
M Korobaeff, and
I Annesi, and
R Liard, and
E Orvoen-Frija, and
F Kauffmann
September 1992,
The American review of respiratory disease,
