Biomaterial Database

Multistep process of squamous differentiation of tracheobronchial epithelial cells: role of retinoids. 1987

A M Jetten

Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, N.C.

The objective of our research is to elucidate the molecular mechanisms that regulate the proliferation and differentiation of tracheobronchial epithelial cells. A clear insight into the basic mechanisms of these processes is required in order to understand the mechanisms involved in tumor development and other pathological conditions. To study the regulation of differentiation of the tracheobronchial epithelium, an in vitro cell culture model was developed using rabbit tracheal epithelial cells. Our studies were directed towards answering the following questions: (1) What is the differentiation capacity of these cells? (2) Does differentiation occur as a multistep process? (3) What factors control differentiation and by what mechanism? (4) What are the biochemical markers for the various differentiated phenotypes and at what level are they controlled? (5) Is there a link between control of cell growth and control of cell differentiation?

UI	MeSH Term	Description	Entries
D010641	Phenotype	The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.	Phenotypes
D012137	Respiratory System	The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.	Respiratory Tract,Respiratory Systems,Respiratory Tracts,System, Respiratory,Tract, Respiratory
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012176	Retinoids	A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.	Retinoid