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Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity. 2020
Qiang Wang, and
Yujiang Li, and
Liyun Zheng, and
Xiaowan Huang, and
Yanli Wang, and
Chin-Ho Chen, and
Yung-Yi Cheng, and
Susan L Morris-Natschke, and
Kuo-Hsiung Lee
High & New Technology Research Center of Henan Academy of Sciences, Zhengzhou 450002, China.
Novel betulinic/betulonic acid-nucleoside hybrids were synthesized as possible new anti-HIV agents. Among the synthesized hybrids, two compounds were highly effective against HIV. Compared with AZT and DSB, compounds 10a (IC50 = 0.0078 μM, CC50 = 9.6 μM) and 10b (IC50 = 0.020 μM, CC50 = 23.8 μM) showed more potent or equipotent, respectively, anti-HIV activity but displayed lower cytotoxicity.
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