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1 A double-blind cross over trial between clonidine, propranolol and a placebo in patients with moderate hypertension has been performed. 2 Thirty-two patients completed the study which consisted of three treatment periods in random order of 3 months each. Patients had their blood pressure recorded by an unbiased observer using a random-zero machine. 3 Both clonidine and propranolol produced a significant reduction in blood pressure (P less than 0.01), which was apparent by the second week of therapy. Propranolol gave a greater reduction in pulse rate than clonidine (P less than 0.01) but clonidine also reduced the pulse rate significantly (P less than 0.05). There was no evidence of postural hypotension on either drug. Side-effects were more common with clonidine but these tended to wear off after several weeks of therapy. 4 Clonidine and propranolol were equipotent in reducing blood pressure, but clonidine has more initial side-effects than propranolol.
P R Wilkinson, and
E B Raftery
June 1980,
Acta neurologica Scandinavica,
P R Wilkinson, and
E B Raftery
January 1979,
British journal of clinical pharmacology,
P R Wilkinson, and
E B Raftery
February 1979,
Archives of internal medicine,
P R Wilkinson, and
E B Raftery
September 1987,
The Journal of clinical psychiatry,
P R Wilkinson, and
E B Raftery
August 1980,
Anesthesiology,
P R Wilkinson, and
E B Raftery
November 1986,
Archives of internal medicine,
P R Wilkinson, and
E B Raftery
January 1974,
Acta medica Scandinavica. Supplementum,
P R Wilkinson, and
E B Raftery
April 1999,
Archives of neurology,
P R Wilkinson, and
E B Raftery
January 1980,
Indian heart journal,
P R Wilkinson, and
E B Raftery
January 1981,
Bollettino della Societa italiana di cardiologia,
