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Secretion of luteinizing hormone (LH) and its beta-subunit (LH-beta) by luteinizing hormone-releasing hormone (LH-RH) were studied in perifused rat anterior pituitary cells. LH release was dose related between 10(-10) and 10(-6)M LH-RH. Every 5-minute pulse of 10(-8)M LH-RH induced almost similar response to the initial LH release; neither the self-priming effect nor desensitization were significant. Continuous administration of 10(-8)M LH-RH caused an initial LH release, followed by distinct desensitization, which could not be overcome by subsequent pulses of 10(-8)M LH-RH. The results were quite similar in LH-beta release. The perifusion study is shown to be useful in analyzing the characteristics of LH and LH-beta release, and the present results suggest that LH-RH receptor-mediated regulation may be also involved in LH-beta release.
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S Tanimoto, and
M Takahashi, and
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March 1995,
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T Seki, and
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T Seki, and
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S Tanimoto, and
M Takahashi, and
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T Seki, and
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Biology of reproduction,
T Seki, and
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S Tanimoto, and
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R Iizuka
March 1991,
Biochimica et biophysica acta,
T Seki, and
T Makino, and
S Tanimoto, and
M Takahashi, and
T Iida, and
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March 1987,
Endocrinology,
T Seki, and
T Makino, and
S Tanimoto, and
M Takahashi, and
T Iida, and
R Iizuka
January 1991,
Life sciences,
T Seki, and
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S Tanimoto, and
M Takahashi, and
T Iida, and
R Iizuka
October 1983,
The Journal of biological chemistry,
