The Sertoli cell is clearly influenced, directly and indirectly, by hormones. Among these are FSH, T, insulin and Vitamin A, but others may also be involved. Mechanisms are still not well understood. The biochemical effects of these hormones can be divided into quantitative and qualitative influences, with the former predominating. Specific cellular and secretory proteins and metabolites are affected, in many cases by more than one hormone. Often these same functions are influenced by other factors in the environment of the testis as well. Hormonal responsiveness of the Sertoli cell is determined in part by the maturational state of the cell. Some secreted products bind to specific cell types in the testis and epididymis and may influence the process of spermatogenesis. However, detailed mechanisms are not known at the present time. Understanding Sertoli cell function at the biochemical level and its control by hormones is clearly of key importance in understanding the control of the spermatogenic process.