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Dietary sodium deprivation lowered blood pressure in patients with essential hypertension, while indomethacin induced a rise in blood pressure with significant decreases in plasma angiotensin II concentration and urinary excretion of sodium and PGE. In contrast, captopril lowered blood pressure in them with significant decrease in plasma angiotensin II concentration and significant increase in urinary excretion of sodium and PGE. These data strongly indicate that the decreased PG generation in the nephron could elevate blood pressure by means of sodium retention caused by the reduced renal excretory function in spite of the decreased R-A system in human, suggesting the involvement of renal tubular PGE2 in the regulation of blood pressure.
K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
December 1980,
Clinical science (London, England : 1979),
K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
July 1983,
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K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
July 1986,
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K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
June 1981,
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K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
January 1979,
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K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
May 1978,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
January 1983,
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K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
November 1978,
Die Medizinische Welt,
K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
June 1984,
Kidney international,
K Abe, and
K Tsunoda, and
M Sato, and
K Omata, and
M Yasujima, and
K Yoshinaga
January 1981,
Pharmacology & therapeutics,
