-transparent.png){kind=logo}
The activity of alcohol dehydrogenase was measured in liver cytosolic fractions of male Fischer 344 rats at ages representing young adulthood, middle age, and old age. The activities were 1.7 +/- 0.1, 2.3 +/- 0.1, and 2.6 +/- 0.2 mumol/min/g liver in rats aged 4-5, 14-15, and 24-25 months, respectively. Hepatic alcohol dehydrogenase activity in female rats (3.4 +/- 0.2 mumol/min/g liver) was the same in young as in old rats. Castration increased alcohol dehydrogenase activity in young males to levels found in females, and testosterone administration reversed the effect. However, neither physiological nor pharmacological doses of the hormone restored the elevated enzyme activities of old male rats to levels found in young male rats.
L E Rikans, and
O R Kling
January 1986,
Toxicology,
L E Rikans, and
O R Kling
December 1980,
Biochemical pharmacology,
L E Rikans, and
O R Kling
December 1973,
Toxicology and applied pharmacology,
L E Rikans, and
O R Kling
June 2004,
The Journal of pharmacy and pharmacology,
L E Rikans, and
O R Kling
October 1995,
Alcoholism, clinical and experimental research,
L E Rikans, and
O R Kling
February 1996,
Alcoholism, clinical and experimental research,
L E Rikans, and
O R Kling
January 1977,
Experimental gerontology,
L E Rikans, and
O R Kling
September 1998,
Experimental gerontology,
L E Rikans, and
O R Kling
May 1982,
The Journal of pharmacology and experimental therapeutics,
L E Rikans, and
O R Kling
January 1991,
Neurobiology of aging,
