Biomaterial Database

A Case-Based Review of Systemic Mastocytosis and Its Cutaneous Manifestations. 2020

Develyn Vetos, and Mandi Greenway Bietz, and B Joel Tjarks, and Renju V Raj

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Mastocytosis represents an uncommon spectrum of disorders where mast cells proliferate and accumulate in different organs and tissues throughout the body, most frequently affecting the skin. Here we present a case of systemic mastocytosis and review the manifestations of cutaneous and systemic mastocytosis to raise awareness and try to reduce the typical delay in diagnosis.

UI	MeSH Term	Description	Entries
D008407	Mast Cells	Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.	Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D034701	Mastocytosis, Cutaneous	Skin lesions due to abnormal infiltration of MAST CELLS. Cutaneous mastocytosis is confined to the skin without the involvement of other tissues or organs, and is mostly found in children. The three major variants are: URTICARIA PIGMENTOSA; diffuse cutaneous mastocytosis; and SOLITARY MASTOCYTOMA OF SKIN.	Cutaneous Mastocytosis,Mastocytosis, Bullous,Mastocytosis, Diffuse Cutaneous,Skin Mastocytosis,Bullous Mastocytoses,Bullous Mastocytosis,Cutaneous Mastocytoses,Cutaneous Mastocytoses, Diffuse,Cutaneous Mastocytosis, Diffuse,Mastocytoses, Bullous,Mastocytoses, Cutaneous,Mastocytoses, Skin,Mastocytosis, Skin,Skin Mastocytoses
D034721	Mastocytosis, Systemic	A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.	Systemic Mast-Cell Disease,Aggressive Systemic Mastocytosis,Indolent Systemic Mastocytosis,Aggressive Systemic Mastocytoses,Indolent Systemic Mastocytoses,Mast-Cell Disease, Systemic,Mast-Cell Diseases, Systemic,Mastocytoses, Aggressive Systemic,Mastocytoses, Indolent Systemic,Mastocytoses, Systemic,Mastocytosis, Aggressive Systemic,Mastocytosis, Indolent Systemic,Systemic Mast Cell Disease,Systemic Mast-Cell Diseases,Systemic Mastocytoses,Systemic Mastocytoses, Aggressive,Systemic Mastocytoses, Indolent,Systemic Mastocytosis,Systemic Mastocytosis, Aggressive,Systemic Mastocytosis, Indolent