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Thymomodulin (Leucotrofina), an orally administrable thymic derivative endowed with interesting immunomodulating and myelomodulating properties, was tested for mutagenicity by means of the following in vitro and in vivo tests: mutagenesis on S. typhimurium with and without metabolic activation system (S-9), gene conversion on S. cerevisiae D 7 with and without metabolic activation, urinary assay in the mouse with and without metabolic activation, urinary assay in the mouse with S. cerevisiae D 7, host mediated assay in the mouse with S. cerevisiae and DNA repair test with and without metabolic activation. On the basis of the results obtained thymomodulin proved to be free of mutagenic activity.
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P Hrelia, and
M Scotti, and
V Scornavacche, and
M Prada
January 1990,
Drugs under experimental and clinical research,
G Cantelli-Forti, and
P Hrelia, and
M Scotti, and
V Scornavacche, and
M Prada
February 1982,
Mutation research,
G Cantelli-Forti, and
P Hrelia, and
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V Scornavacche, and
M Prada
November 1986,
Arzneimittel-Forschung,
G Cantelli-Forti, and
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January 1975,
Mutation research,
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G Cantelli-Forti, and
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September 1987,
Mutagenesis,
G Cantelli-Forti, and
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V Scornavacche, and
M Prada
December 1996,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
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M Scotti, and
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M Prada
October 1982,
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