Biomaterial Database

Evaluation of Low-Temperature Sterilization using Hydrogen Peroxide Gas Containing Peracetic Acid. 2020

Minoru Noda, and Yoshinobu Sakai, and Yoshiro Sakaguchi, and Nobuya Hayashi

Saga University Hospital Medical Engineering Center.

In low-temperature sterilization for the medical field, hydrogen peroxide sterilization is widely used for its safety. However, its low penetrability and residual amount of sterilant are major concerns. Recently, the combination of hydrogen peroxide and peracetic acid has been found to enforce sporicidal effect, with low concentration in hydrogen peroxide. The application of this finding in medical sterilization is still very limited. To elucidate the combination effect, we compare peracetic acid containing hydrogen peroxide gas sterilizer and conventional hydrogen peroxide gas (plasma) sterilizers. The sterilant penetrability was examined in hollow load process challenge devices with inner diameters of 1 and 2 mm and lengths of 1, 2, and 3 m. As a result, peracetic acid containing hydrogen peroxide gas sterilizer demonstrated total inactivation with all diameters and lengths and achieved the highest sterilant penetrability in this study. The amount of residual sterilant on the surface of the sterilized object was 4.2 μg/cm2, which corresponds to half amount of those of conventional hydrogen peroxide gas sterilizers. These results suggest that the addition of peracetic acid to hydrogen peroxide gas sterilizer can enhance sterilization efficiency and safety.

UI	MeSH Term	Description	Entries
D010463	Peracetic Acid	A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant.	Acetyl Hydroperoxide,Peroxyacetic Acid,Desoxone-1,Dialax,Peracetic Acid, Sodium Salt,Peroxyethanoic Acid,Sodium Peracetate,Zinc Peracetate,Acid, Peracetic,Acid, Peroxyacetic,Acid, Peroxyethanoic,Desoxone 1,Desoxone1,Peracetate, Sodium,Peracetate, Zinc
D003080	Cold Temperature	An absence of warmth or heat or a temperature notably below an accustomed norm.	Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D005740	Gases	The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
D006861	Hydrogen Peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.	Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D013242	Sterilization	The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
D058626	Plasma Gases	Ionized gases, consisting of free electrons and ionized atoms or molecules which collectively behave differently than gas, solid, or liquid. Plasma gases are used in biomedical fields in surface modification; biological decontamination; dentistry (e.g., PLASMA ARC DENTAL CURING LIGHTS); and in other treatments (e.g., ARGON PLASMA COAGULATION).	Cold Plasma,Non-Thermal Atmospheric Pressure Plasma,Thermal Plasma,Gases, Plasma,Non Thermal Atmospheric Pressure Plasma,Plasma, Cold,Plasma, Thermal