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Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis. 2021
Hugo Helbert, and
Ines Farinha Antunes, and
Gert Luurtsema, and
Wiktor Szymanski, and
Ben L Feringa, and
Philip H Elsinga
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands. b.l.feringa@rug.nl.
The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging.
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