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In a study of multicase RA families, significantly raised frequencies of the HLA antigens DR4, DR1, Bw62, Cw3, A2, A31 and significantly lower frequencies of DR2, DR3, and B8 were found in probands compared to normal controls. When haplotype frequencies were compared between probands and controls, two haplotypes A2-B44-DR4 and A2-Bw62-DR4 were at higher frequency in probands. These differences no longer reached significance when only DR4-containing haplotypes were compared between probands and controls. A significantly lower haplotype frequency of A1-B8-DR3 was observed in probands compared to controls. This difference did not remain significant when only non-DR4 haplotypes were compared. Using an affected sibling pair ratio method, significant linkage between HLA and RA was found (P less than 0.01). Significant linkage was also observed between HLA and seropositivity. Analysis of Hardy-Weinberg equilibrium for the DR locus did not support the suggestion that DR4-associated RA susceptibility was inherited as a dominant trait. In addition it did not support the notion of an additive effect of DR4 and DR1 in RA susceptibility as these antigens were not found together more frequently than predicted by their individual gene frequencies.
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
January 1987,
Arthritis and rheumatism,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
November 1995,
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W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
June 1991,
British journal of rheumatology,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
June 2001,
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W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
January 1993,
Scandinavian journal of rheumatology,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
October 1993,
Arthritis and rheumatism,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
March 2004,
Arthritis and rheumatism,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
April 1986,
Annals of the rheumatic diseases,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
February 1993,
The Journal of rheumatology,
W Ollier, and
A Silman, and
N Gosnell, and
H Currey, and
J Awad, and
P Doyle, and
D McCloskey, and
A Alonso, and
M A Hossain, and
H Festenstein
April 1997,
Annals of the New York Academy of Sciences,
