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The Pediatric Rheumatology Collaborative Study Group was established in 1973 to undertake systematic trials of new drugs in the treatment of juvenile rheumatoid arthritis. The first drug evaluated was tolmetin (1-methyl-5-p-toluoylpyrrole-2 acetic acid), a new nonsteroid anti-inflammatory agent. A four-week open trial with 30 patients and a subsequent 12-week double-blind trial against aspirin with 107 patients were conducted. Tolmetin and aspirin had equal anti-inflammatory and analgesic effects in the treatment of JRA. Elevations of transaminase values attributed to aspirin were not found with tolmetin. Adverse effects accompanying administration of tolmetin did not appear to be of major clinical significance.
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
October 1981,
Arthritis and rheumatism,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
July 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
May 1956,
British medical journal,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
January 1976,
Current medical research and opinion,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
March 1979,
Minerva pediatrica,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
January 1982,
The Journal of rheumatology,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
September 1985,
American journal of diseases of children (1960),
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
January 1976,
Current medical research and opinion,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
May 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J E Levinson, and
J Baum, and
E Brewer, and
C Fink, and
V Hanson, and
J Schaller
January 1983,
Scandinavian journal of rheumatology,
