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The possibility that immunological mechanisms are involved in the development of tolerance to the analgesic effect of morphine was investigated, focusing on several immunological parameters. The data indicate that transfer of spleen cells and bone marrow cells obtained from morphine-tolerant donors into nontolerant syngeneic recipient mice did not result in the transfer of tolerance to the analgesic activity of morphine. Furthermore, the data indicate that the thymus, which is essential for the immunological response to many antigens, was not involved in the induction of tolerance to the opiate since tolerance was induced in thymectomized mice as well as in genetically athymic mice. The results suggest that immunological factors do not seem to play a crucial role in the phenomenon of tolerance to the analgesic activity of morphine.
C H Miller, and
W D Winters, and
E Benjamini
February 1972,
Immunology,
C H Miller, and
W D Winters, and
E Benjamini
March 2016,
Clinical biochemistry,
C H Miller, and
W D Winters, and
E Benjamini
November 1989,
Science (New York, N.Y.),
C H Miller, and
W D Winters, and
E Benjamini
January 1984,
Survey of immunologic research,
C H Miller, and
W D Winters, and
E Benjamini
October 1960,
Annals of allergy,
C H Miller, and
W D Winters, and
E Benjamini
January 1977,
Folia biologica,
C H Miller, and
W D Winters, and
E Benjamini
May 1979,
Pharmacology, biochemistry, and behavior,
C H Miller, and
W D Winters, and
E Benjamini
October 2018,
Current opinion in immunology,
C H Miller, and
W D Winters, and
E Benjamini
July 1993,
Regulatory peptides,
C H Miller, and
W D Winters, and
E Benjamini
September 2012,
Seminars in immunopathology,
