Assessment of Ablation Therapy in Pancreatic Cancer: The Radiologist's Challenge. 2020

Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
Radiology Division, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Naples, Italy.

This article provides an overview of imaging assessment of ablated pancreatic cancer. Only studies reporting radiological assessment on pancreatic ablated cancer were retained. We found 16 clinical studies that satisfied the inclusion criteria. Radiofrequency ablation and irreversible electroporation have become established treatment modalities because of their efficacy, low complication rates, and availability. Microwave Ablation (MWA) has several advantages over radiofrequency ablation (RFA), which may make it more attractive to treat pancreatic cancer. Electrochemotherapy (ECT) is a very interesting emerging technique, characterized by low complication rate and safety profile. According to the literature, the assessment of the effectiveness of ablative therapies is difficult by means of the Response Evaluation Criteria in Solid Tumors (RECIST) criteria that are not suitable to evaluate the treatment response considering that are related to technique used, the timing of reassessment, and the imaging procedure being used to evaluate the efficacy. RFA causes various appearances on imaging in the ablated zone, correlating to the different effects, such as interstitial edema, hemorrhage, carbonization, necrosis, and fibrosis. Irreversible electroporation (IRE) causes the creation of pores within the cell membrane causing cell death. Experimental studies showed that Diffusion Weigthed Imaging (DWI) extracted parameters could be used to detect therapy effects. No data about functional assessment post MWA is available in literature. Morphologic data extracted by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) do not allow to differentiate partial, complete, or incomplete response after ECT conversely to functional parameters, obtained with Position Emission Tomography (PET), MRI, and CT.

UI MeSH Term Description Entries

Related Publications

Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
April 1978, New York state journal of medicine,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
December 2003, American journal of surgery,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
January 2003, International journal of gastrointestinal cancer,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
January 1999, Radiographics : a review publication of the Radiological Society of North America, Inc,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
December 2017, Anesthesiology clinics,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
August 2017, Emergency radiology,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
March 2013, Oncology (Williston Park, N.Y.),
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
January 2006, HPB : the official journal of the International Hepato Pancreato Biliary Association,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
January 2019, Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti,
Vincenza Granata, and Roberta Grassi, and Roberta Fusco, and Sergio Venanzio Setola, and Raffaele Palaia, and Andrea Belli, and Vittorio Miele, and Luca Brunese, and Roberto Grassi, and Antonella Petrillo, and Francesco Izzo
November 2016, World journal of gastroenterology,
Copied contents to your clipboard!