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LncRNA LncOGD-1006 alleviates OGD-induced ischemic brain injury regulating apoptosis through miR-184-5p/CAAP1 axis. 2020
Department of Neurology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, China. iiorfguj@163.com.
This study aimed to explore the effect of long non-coding RNA (LncRNA) LncOGD-1006 to ischemic stroke and the possible mechanism. The primary brain microvascular endothelial cells (bEnd.3) of oxygen-glucose deprivation (OGD) was used as a mimic of ischemic stroke in vitro. The results showed that LncOGD-1006 was upregulated in bEnd.3 after OGD-induced. LncOGD-1006 might act as a ceRNA to inhibit apoptosis in bEnd.3 cells by targeting miR-184-5p/CAAP1 pathway.
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