We investigate the azimuthal angular correlation between the lepton transverse momentum P_{⊥} and the impact parameter b_{⊥} in noncentral heavy-ion collisions, where the leptons are produced through two-photon scattering. Among the Fourier harmonic coefficients, a significant v_{4} asymmetry is found for the typical kinematics at RHIC and LHC with a mild dependence on the P_{⊥}, whereas v_{2} is power suppressed by the lepton mass over P_{⊥}. This unique prediction, if confirmed from the experiments, shall provide crucial information on the production mechanism for the dilepton in two-photon processes.