Fundamental to the clinical application of somatosensory evoked potentials is an understanding of the neural generators, the changes in disease states, and the effects of growth and maturation; aspects relevant to pediatric somatosensory evoked potentials were discussed previously (Part I). The importance of establishing normative data across age- and size-matched controls in the pediatric population, however, cannot be overstated. The following review of the clinical applications of somatosensory evoked potentials in pediatric neurology is based on a review of the literature and on the experience gained from over 900 studies performed in our laboratory during the last 4 years.