Age and gender related differences in load-strain response in C57Bl/6 mice. 2020

Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
University of Missouri-Kansas City, Department of Civil and Mechanical Engineering, Kansas, MO 64110, USA.

We examined the changes in mechanical strain response of male and female mouse tibia and ulna, using axial compression tests, to assess age-related changes in tibiae and ulnae by a non-contact strain measurement technique called the digital image correlation (DIC) and the standard strain gage. A unique aspect of the study was to compare bones from the same animal to study variations in behavior with aging. This study was conducted using male and female C57Bl/6 mice at 6, 12 and 22 months of age (N=6-7 per age and sex) using three load levels. The DIC technique was able to detect a greater number of statistically significant differences in comparison to the strain gaging method. Male ulna showed significantly higher DIC strains compared to strains captured from strain gage at all three levels of load at 6 months and in the lowest load at 12 months. DIC measurements revealed that the ulna becomes stiffer with aging for both males and females, which resulted in 0.4 to 0.8 times reduced strains in the 22-month group compared to the 6 month group. Male tibia showed three-fold increased strains in the 22 months group at 11.5 N load compared to 6 months group (p<.05).

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D005260 Female Females
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012727 Sex Characteristics Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction. Gender Characteristics,Gender Differences,Gender Dimorphism,Sex Differences,Sex Dimorphism,Sexual Dichromatism,Sexual Dimorphism,Characteristic, Gender,Characteristic, Sex,Dichromatism, Sexual,Dichromatisms, Sexual,Difference, Sex,Dimorphism, Gender,Dimorphism, Sex,Dimorphism, Sexual,Gender Characteristic,Gender Difference,Gender Dimorphisms,Sex Characteristic,Sex Difference,Sex Dimorphisms,Sexual Dichromatisms,Sexual Dimorphisms
D013314 Stress, Mechanical A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area. Mechanical Stress,Mechanical Stresses,Stresses, Mechanical
D013977 Tibia The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally. Tibias
D014457 Ulna The inner and longer bone of the FOREARM. Semilunar Notch,Trochlear Notch,Ulnar Coronoid Process,Ulnar Trochlear Groove,Coronoid Process, Ulnar,Semilunar Notchs,Trochlear Groove, Ulnar,Trochlear Notchs,Ulnar Coronoid Processes,Ulnar Trochlear Grooves,Ulnas
D016474 Weight-Bearing The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot. Load-Bearing,Axial Loading,Loadbearing,Weightbearing,Axial Loadings,Load Bearing,Weight Bearing

Related Publications

Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
May 2009, Investigative ophthalmology & visual science,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
January 2018, Adipocyte,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
January 1992, Alcohol (Fayetteville, N.Y.),
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
July 2006, Experimental animals,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
January 2005, Physiological research,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
March 2010, Neuroscience letters,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
July 2009, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
March 2011, Age (Dordrecht, Netherlands),
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
March 2021, Biomolecules,
Hammad Mumtaz, and Nuria Lara-Castillo, and JoAnna M Scott, and Mark Begonia, and Mark Dallas, and Mark L Johnson, and Thiagarajan Ganesh
May 2008, Neurotoxicology,
Copied contents to your clipboard!