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Photodynamic therapy (PDT) was performed utilizing a cylindrical optical fiber to determine feasibility of distal ureteral treatment on 10 study and two control NIH foxhounds. The study animals were administered three mg./kg. dihematoporphyrin ether (Photofrin II) intravenously followed 48 hours later by open cystotomy. One ureter was irradiated with 42 joules of 630 nm. light delivered by a 660 micron diameter optical fiber modified for cylindrical light distribution. Intravenous urography was performed both at three days and six weeks post PDT. Hydroureteronephrosis was revealed in one treated ureter and one untreated ureter. Mild dilatation of the ureter was noted by urography in another treated ureter and in one ureter that did not undergo light irradiation; no distal obstruction was revealed in either case by proximal infusion of saline or by histopathology. Nine of the 10 treated ureters were found to have either no abnormal pathology or only minimal lymphocytic infiltration. In this study, the normal ureter was shown to tolerate photodynamic therapy at energy densities equivalent to those used to effect tumor regression and the feasibility of using a cylindrical optical fiber for treatment of ureteral malignancies was confirmed.
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
January 1986,
Lasers in surgery and medicine,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
May 1974,
Investigative urology,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
May 1993,
Photochemistry and photobiology,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
January 1991,
Lasers in surgery and medicine,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
April 1993,
Urology,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
November 1990,
Photochemistry and photobiology,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
September 2023,
The Prostate,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
March 2001,
Clinical cancer research : an official journal of the American Association for Cancer Research,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
January 1994,
Lasers in surgery and medicine,
M J Manyak, and
D M Matthews, and
P D Smith, and
L E Nochomovitz, and
E Glatstein, and
A Russo
October 1991,
Neurosurgery,
