OBJECTIVE This paper studies the abilities of a twin-robotic x-ray slot-scanning system for orthopedic imaging to reduce dose by scatter rejection compared to conventional digital radiography. METHODS We investigate the dose saving capabilities, especially in terms of the signal- and the contrast-to-noise ratio, as well as the scatter-to-primary ratio of the proposed slot-scanning method in comparison to the state-of-the-art method for length-extended imaging. As a baseline, we use x-ray parameters of two clinically established acquisition protocols that provide the same detector entrance dose but are profoundly different in patient dose. To obtain an estimate of the photon-related noise directly from an x-ray image, we implement a Poisson-Gaussian noise model. This model is used to compare the dose efficiency of two settings and combined with the well-known to determine the transmission parameters. We present a method with an associated measurement protocol, utilizing the robotic capabilities of the used system to automatically obtain quasi-scatter-free ground-truth data with exact geometric correspondence to full-field and slot acquisitions. In total, we investigate two body regions (thoracic spine and lumbar spine) in anterior-posterior view with two patient sizes (BMI = 22 and 30) in two acquisition modes (conventional and slot scan with a flat-panel detector) with and without anti-scatter grid using an anthropomorphic upper-body phantom. RESULTS We have shown that it is feasible to combine the proposed approach with the for the determination of scatter rejection parameters. The use of an anti-scatter grid is indicated for full-field acquisitions allowing for dose savings up to 46% compared to their gridless counterparts. When changing the acquisition mode to the investigated slot scan, the use of an anti-scatter grid has no major impact on the image quality in terms of dose efficiency, in particular for patients with a BMI of 22. However, an increased contrast improvement factor was found. For normal-sized patients, up to 53% of dose can be saved additionally in comparison to full-field acquisitions with grid. Moreover, we could demonstrate that a slot size of 5 cm and air gap of 10 cm is sufficient to achieve scatter-to-primary ratios, which are equal or better compared to those of the full-field acquisitions with a grid. CONCLUSIONS We have shown, that the slot-scanning approach is always superior to the conventional full-field acquisition in terms of signal-to-noise and scatter-to-primary ratios. Compared to the state-of-the-art acquisition protocols with a grid, dose savings up to 53% are possible due to the scatter rejection without compromising the SNR. Hence, the use of the slot-scanning method is indicated, especially when it comes to regularly carried-out follow-up acquisitions, for example, in the case of scoliosis monitoring.