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To test the hypothesis that amniotic fluid directly affects cardiac function, isolated rat hearts were perfused with varying concentrations of centrifuged and filtered human amniotic fluid. The most consistent change seen was a dose-dependent decrease in coronary flow rate. With 10% concentrations, a wide spectrum of changes was seen in both a positive and a negative direction for left ventricular pressure and change in pressure with respect to time, which were closely correlated with the degree of decrease in coronary flow rate. If amniotic fluid has a direct role in depressing cardiac function in amniotic fluid embolism, it may act by decreasing coronary flow rather than by directly suppressing myocardial activity.
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
January 1987,
Proceedings of the Western Pharmacology Society,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
April 1992,
Nihon hoigaku zasshi = The Japanese journal of legal medicine,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
January 2001,
Experimental and clinical cardiology,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
January 1989,
The Japanese journal of physiology,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
June 1980,
Journal of molecular and cellular cardiology,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
March 1997,
Zhonghua fu chan ke za zhi,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
February 1996,
Acta physiologica Scandinavica,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
September 1990,
Clinical science (London, England : 1979),
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
May 1971,
Canadian journal of physiology and pharmacology,
D S Richards, and
L S Carter, and
B Corke, and
F Spielman, and
R C Cefalo
January 1990,
Free radical biology & medicine,
